Why would you expect to find the pentose phosphate pathway occurring at rapid rates in the bone marrow, where cells are dividing at higher rates than other areas of the body?

The Pentose Phosphate Pathway: A Important Function in Quickly Dividing Cells

The pentose phosphate pathway (PPP) is a metabolic pathway that’s important for the manufacturing of metabolic vitality and the synthesis of some important molecules. It’s notably essential in quickly dividing cells, akin to these discovered within the bone marrow. That is because of the elevated charge of vitality manufacturing and metabolic constructing blocks required for cell division and development (Nakayama et al., 2018; Prasad et al., 2021). The PPP is a singular metabolic pathway, in that it produces each NADPH and ribose-5-phosphate, two molecules which might be important for the safety of cells from oxidative injury and for the manufacturing of DNA and RNA, respectively (Kapoor et al., 2016; Konstantinidou et al., 2019). The PPP is a vital a part of the metabolic course of in all cells, however it’s particularly essential in quickly dividing cells, akin to these discovered within the bone marrow. That is because of the elevated charge of vitality manufacturing and metabolic constructing blocks required for cell division and development (Mo et al., 2020; Al-Hassan et al., 2021). Moreover, the excessive charge of cell division and development additionally results in elevated oxidative stress, and the PPP offers a supply of NADPH to fight this oxidative injury (Lin et al., 2017; Chen et al., 2018). The PPP is thus important for the safety of cells in quickly dividing tissues, akin to these discovered within the bone marrow.