The Penalties of Aberrant Cross Over Involving Inverted Repeat Sequences
Chromosomal rearrangements, or modifications in chromosome construction, are sometimes brought on by aberrant crossing over of inverted repeat sequences on the identical chromosome. Inverted repeat sequences are quick stretches of nucleotide sequences which can be repeated within the reverse orientation. Throughout meiosis, the method of cell division that produces gametes, the crossing over of inverted repeat sequences can result in chromosomal rearrangements. Relying on the precise location and sort of inverted repeat sequence, the ensuing chromosomal rearrangements could cause quite a lot of results, each constructive and detrimental (Jiang et al., 2016; Bani and Milani, 2021). One such sort of chromosomal rearrangement that may consequence from aberrant crossing over of inverted repeat sequences on the identical chromosome is a reciprocal translocation. In a reciprocal translocation, two non-homologous chromosomes trade segments with one another (Kumar and Rost, 2018). This could trigger quite a lot of genetic structural modifications, resembling modifications in gene expression and gene regulation, which might have important results on phenotype (Pon et al., 2020).