Which of the following statements is true about loss-of-function mutations in human genomes? The Truth about Loss-of-Function Mutations in Human Genomes

Discover the truth about loss-of-function mutations in human genomes

Loss-of-function mutations in human genomes refer to any mutation that decreases or eliminates the gene’s normal activity. There are many factors that can cause these mutations, such as genetic and environmental changes. Although loss-of function mutations may cause many diseases, some can be advantageous. To make educated decisions regarding our health, it is crucial to fully understand what loss-of function mutations can do to your body. A common form of loss-of function mutation is found in genes BRCA1 and BRCA2. Brodie and colleagues, 2019, found that these mutations increase the risk of breast cancer and ovarian cancer. A loss-of function mutation that is linked to cystic fibrosis is another example (Striano et. al. 2020). It is possible to be beneficial if you have a loss-of-function mutation. One example is the CCR5 mutation, which has been linked to resistance to HIV-1 infection. (Hoffmann, et al. 2016). In addition, some studies have suggested that loss-of-function mutations in the APOE gene can reduce the risk of Alzheimer’s disease (Bertram et al., 2021). Cont….