The Effect of Not Adding Proline Catalyst in the Enantiomeric Excess and Mosher’s Ester Configurational Analysis of Chiral Aldol (4-hydroxy-4-(2-nitrophenyl)butane-2-one)
For determining the stereochemistry of a compound, you can use the enantiomeric excessive (EE) or Mosher’s ester configurational analysis for chiral aldol. This reaction can be affected by the addition of a proline catalyst. The reaction won’t produce the expected results without the proline catalyst (Chen and colleagues, 2019; Li and co-workers, 2020).
Due to the absence of stereoselectivity, the reaction might not achieve the desired amount. A lack of an efficient catalyst could also lead to incorrect results in the Mosher’s ester configurational analyses (Chen, et al. 2019, 2019). Proline catalyst is essential for the formation of desired chiral aldol products (Chen and al., 2019,). It is essential to ensure that the desired reaction takes place and produces the expected results. To achieve the desired result in the enantiomeric excess or Mosher’s ester configurational analyses of chiralaldol, a proline catalyst must be added. The reaction won’t proceed as planned and you will not get the results that you want. When performing such reactions, it is crucial to add the proline catalytic.