We have discussed several diseases associated with unstable trinucleotide repeats. Name three examples of these diseases and detail the technology that you would use to determine if an individual carried one or more defective genes. Identifying Trinucleotide Repeat Disorders with DNA Testing

Figuring out Trinucleotide Repeat Problems with DNA Testing

Trinucleotide repeat issues (TRDs) are a bunch of genetic illnesses attributable to an growth of trinucleotide repeats in particular genes. These repeats could cause quite a lot of neurological and neuromuscular issues, and three of the commonest TRDs are fragile X syndrome, myotonic dystrophy sort 1, and Huntington’s illness. DNA testing is essentially the most dependable approach to decide if a person carries a number of faulty genes related to these illnesses. Fragile X syndrome is attributable to an growth of CGG trinucleotide repeats within the FMR1 gene, and is the commonest inherited type of mental incapacity (Raymond et al., 2020). DNA testing for this illness entails amplifying the FMR1 gene to find out the variety of CGG repeats and establish people who’ve the disease-causing mutation. Myotonic dystrophy sort 1 is attributable to an growth of a CTG trinucleotide repeat within the DMPK gene (Kapoor et al., 2017). DNA testing for this illness entails amplifying the DMPK gene to find out the variety of CTG repeats and establish people who’ve the disease-causing mutation. Huntington’s illness is attributable to an growth of CAG trinucleotide repeats within the HTT gene (Liu et al., 2021). DNA testing for this illness entails amplifying the HTT gene to find out the variety of CAG repeats and establish people who’ve the disease-causing mutation. Cont…