Using a range of the publicly available tools and resources that you have explored this week, identify potentially altered genes / proteins and investigate these further. Identifying Altered Genes and Proteins: Exploring Publicly Available Tools and Resources

How to identify altered genes and proteins: Explore publicly available tools and resources

The human genome is composed of a vast number of genes and proteins, and the identification of any changes or alterations in these components can provide valuable insight into the functioning of the body’s systems. It is therefore essential to identify altered proteins and genes as part of continuing medical research. We will be discussing some public resources and tools that are available to help identify and further investigate potentially altered proteins and genes. There are many resources available from the National Center for Biotechnology Information that can help you identify and examine altered proteins. The NCBI’s Gene Expression Omnibus (GEO) is a publicly accessible database that contains gene expression data from over one million samples (Langmead et al., 2020). Additionally, the NCBI’s BLAST (Basic Local Alignment Search Tool) is a powerful tool for comparing genetic sequences, which can be used to identify changes in gene sequences (Altschul et al., 1990). For identifying genes and proteins that have been altered, the University of California Santa Cruz Genome Browser can be a useful resource. You can access a variety of databases through this browser. For example, the Ensembl Genomes web browser contains information on more than 100 species of animals, plants, fungi, and protists (Kersey and al., 2016). The Genome Browser provides direct access to Variant Annotation Integrator, which offers a variety of tools for identifying and investigating genetic variation. (Zerbino, 2021). Cont….


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