Immunotherapy: The Role Of DNA Repair Factors In Enhancing the Efficacy
An increasing number of evidences linking DNA damage factor inhibition and immunotherapy efficacy has led to a deeper exploration of the causes. The increased effectiveness of immunotherapy may result from the disruption of the cGAS–STING pathway (Ma et. al., 2018,). Another hypothesis suggests that DNA repair factor defects or inhibitions, like mismatch repair proteins may cause an increase in DNA damage. This could then be detected by the immune system and allow for enhanced immunotherapy (Kumar, et al. 2020). These hypotheses could be tested by allowing tumor cells to be infected with various DNA repair proteins. Then, the immune system can evaluate the cell’s response to the immunotherapy. The tumor’s expression of mismatch repair proteins can also be evaluated and linked to immunotherapy effectiveness. These hypotheses can be further supported by further analyses of various DNA repair pathways, and their effects upon tumor antigens. The experiments can provide information about the roles of DNA repair genes in the effectiveness of immunotherapy. Cont….