The S549N CFTR allele results in a CFTR protein that is made and moves to the cell surface, however, the channel gate does not open properly. Explain how this mutation would affect the movement of chloride ions and water molecules into and out of the cell. The Impact of the S549N CFTR Allele on the Movement of Chloride Ions and Water Molecules

The Influence of the S549N CFTR Allele on the Motion of Chloride Ions and Water Molecules

The S549N CFTR allele is a genetic mutation that impacts the operate of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, leading to a protein that’s made and transported to the cell floor, however the channel gate doesn’t open correctly. This mutation impacts the motion of chloride ions and water molecules into and out of the cell, because it causes a lower in chloride ion transport and a lower in transepithelial water transport (Chamorro et al., 2017; Kielb et al., 2020). Particularly, the S549N CFTR allele ends in a lower in chloride ion transport throughout the cell membrane, because the improperly opened channel gate fails to permit chloride ions to cross by. This ends in a discount within the chloride ion focus, resulting in a lower within the osmolarity of the extracellular fluid (Kielb et al., 2020). Moreover, this lower in chloride ion transport additionally impacts the motion of water molecules, because the decreased osmolarity of the extracellular fluid causes a lower within the osmotic gradient, decreasing the motion of water molecules from the extracellular fluid to the intracellular house (Chamorro et al., 2017). Cont…