The human b-globin gene has two alleles, HS and HA. Individuals that are homozygous for HS have sickle-cell anemia and a lower fitness. Individuals that are heterozygotes (HSHA) do not show sickle-cell symptoms and have a resistance to malaria. Individuals that are homozygous for HA have the highest fitness but are susceptible to malaria. If a vaccine for malaria was created that was 100% effective, affordable, and widely available, what would happen to the frequency of the HS allele? The Impact of a Malaria Vaccine on the Frequency of the Human ?-globin HS Allele

The Affect of a Malaria Vaccine on the Frequency of the Human ?-globin HS Allele 

The human ?-globin gene has two alleles, HS and HA, which can be related to totally different ranges of health. Homozygous HS people have sickle-cell anemia and decrease health, whereas heterozygous HSHA people have a resistance to malaria however a standard health. Homozygous HA people have the very best health however are most prone to malaria (Kumar, 2020). Thus, if a malaria vaccine was created that was 100% efficient, inexpensive, and extensively accessible, the frequency of the HS allele can be anticipated to lower within the inhabitants. This lower within the HS allele is because of the truth that the vaccine would get rid of the selective benefit of the HSHA genotype, which is the resistance to malaria. Because of this, the HS allele would now not present a protecting benefit, resulting in a lower in its frequency (Giammanco et al., 2019). Moreover, the supply of the malaria vaccine may scale back the prevalence of malaria in endemic areas, additional reducing the selective benefit of the HS allele. Cont….