The development of a ? which contains telomeres, a centromere, and origins of replication, would allow encoding of the entire DMD gene and its regulatory sequences for potential gene therapy applications in DMD patients. Exploring the Potential of Gene Therapy Applications in Duchenne Muscular Dystrophy Patients through the Development of a Construct Containing Telomeres, Centromere, and Origins of Replication

Exploring the Potential of Gene Remedy Purposes in Duchenne Muscular Dystrophy Sufferers by means of the Improvement of a Assemble Containing Telomeres, Centromere, and Origins of Replication

Duchenne muscular dystrophy (DMD) is a extreme, progressive type of muscular dystrophy attributable to mutations within the dystrophin gene (Kadkhodaei et al., 2021). Whereas there are presently no authorized therapies for DMD, gene remedy holds potential for therapeutic interventions. To this finish, the event of a assemble containing telomeres, a centromere, and origins of replication would enable for the encoding of the whole DMD gene and its regulatory sequences (Gueye et al., 2016). The inclusion of telomeres, that are specialised DNA sequences that act as a protecting cap on the ends of chromosomes, would guarantee the steadiness of the assemble as soon as it’s built-in into the host genome. The centromere, which is a area of DNA that’s important for the correct segregation of chromosomes throughout cell division, would enable for the expression of the assemble in various cells. Lastly, the inclusion of origins of replication, that are areas of DNA that enable for the replication of the assemble, would facilitate the environment friendly expression of the assemble within the goal cells. Cont…