The Asymmetric Hydrogenation of Alkenes: Predicting Stereochemical Outcomes

The Prediction of Stereochemical Outcomes by Asymmetric Hydrogenation

Because it produces enantiomerically pure products, the asymmetric hydrogenation of alkenes can be an important organic chemical reaction. It is important to understand the stereochemical outcomes of reactions in order to synthesize compounds that have desired properties. A compound with a particular stereochemistry might have higher bioavailability and greater reactivity than its non-stereospecific equivalents, (Lambert, et al. 2019, 2019). Understanding the reaction mechanism of the catalyst and its stereochemistry can help determine the stereochemistry. This reaction involves a syn-addition of hydrogen atoms with the double bond of alkene to form a planar intermediate that then enters a transitional state. The transition state is where the hydrogen atoms of the product are rearranged. Stereochemistry of chiral centres is determined by their geometry, which is driven in part by stereochemistry of catalysts (Lambert and al., 2019).

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