Metabolic Reactions of Drugs and Endogenous Substances

Metabolic Reactions of Drugs and Endogenous Substances

Complex biochemical reactions that involve drugs or endogenous substances, such as metabolic reactions, are common in the human body. This is a process that involves the conversion of reactants to products and it’s mainly catalyzed primarily by enzymes. The most important part of metabolic reactions is the removal of endogenous and drugs from the body. Three common types of metabolic reactions are covered in this article, including SN1, radical and E1 reactions. The SN1 reaction is a carbocation intermediary, which results from a proton to electrophile transfer. The SN1 reaction is used to produce cortisol, an endogenous chemical, using cytochrome P450 and CYP enzymes. (Chan et.al., 2019). This electrophile refers to a hydroxyl and nucleophile to a proton. Radical reactions are the formation of radical intermediates and are often initiated by an external source such as ultraviolet radiation (Cline et. al., 2016,). The radical reaction is responsible for the metabolism of ibuprofen by the RXRCYP enzyme complex.