I was asked about FISH and its application in genetics, can you give me a little explanation?

FISH: A Highly effective Instrument in Genetics

Fluorescence in situ hybridization (FISH) is a robust software utilized in genetics to visualise the situation of particular DNA sequences inside a cell. It’s used to review genetic illnesses, chromosomal abnormalities, gene mapping, and extra. FISH works by taking a pattern of cells and tagging a particular DNA sequence with a fluorescent molecule. The tagged cells are then seen beneath a fluorescent microscope to determine their actual location throughout the cell. FISH is a invaluable software for understanding genetic illnesses. It may be used to determine particular chromosomal abnormalities related to illnesses corresponding to Down syndrome and Duchenne muscular dystrophy (DMD). It may also be used to create detailed genetic maps. For instance, it was used to create the primary high-resolution map of the human genome in 2003 (Venter et al., 2003).
FISH can be utilized in most cancers analysis, as it could possibly assist determine the precise forms of genetic mutations related to sure forms of most cancers. It is usually used to evaluate the effectiveness of focused most cancers therapies. For instance, in 2020, researchers used FISH to evaluate the effectiveness of a focused remedy for CLL (power lymphocytic leukemia) in a scientific trial (Steidl et al., 2020).

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