Explain the below mutation for Duchenne Muscular Dystrophy disease including the transcriptional and translational aspects , how does it affect the DNA and mRNA sequence is it a duplication, deletion or insertion? The Impact of Duplication Mutation on Duchenne Muscular Dystrophy Disease

Duchenne Muscular Dystrophy Disease: The Effect of Duplication Mutation

Duchenne Muscular Dystrophy is caused by a dystrophin mutation (Kong and al., 2021). Frameshift is a result of the duplication mutation. This frameshift occurs when a single or multiple base(s) are inserted in a gene. It alters DNA and mRNA sequencing (Muller, 2020). Dystrophin is produced when bases are inserted into a gene. This protein is vital for the proper functioning of the muscle (Kong and al., 2021). DMD patients eventually need a wheelchair and experience muscle weakness (Muller, 2020). DMD’s transcriptional component involves adding extra bases to alter the codon sequence (Kong and al., 2021). An abnormal codon results in an early termination codon which causes the dystrophin protein to be produced (Muller, et al. 2020). DMD is caused by the inability of the truncated protein to fulfill its function as a muscle-stabilizing protein. This causes muscle weakness. Cont….

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