DNA double strand breaks are considered the most dangerous kind of cellular reactions carrying a high risk of endangering the life of a cell when it occurs. However, there are a number of normal cellular processes in eukaryotic cells that produce DNA double stranded breaks. Select 2 of these natural processes and for each one: Explain in detail the biological rationale of this process. The Biological Rationale Behind DNA Double Strand Breaks in Eukaryotic Cells

Eukaryotic DNA Double Strand Breaks: The Biological Reason

The most deadly type of cellular response, DNA double strand break (DSB) is extremely dangerous and can endanger a cell’s ability to function properly. This is why so much effort has been made to understand how these breaks happen. These DNA DSBs can be caused in a number of ways, including radiation and chemical exposure. However, many natural processes occur within eukaryotic cells, which may also cause them. Homologous recombination is one of the natural processes, while non-homologous ending joining is another. The process of homologous reproduction is when two identical chromosomes share genetic material. This type of genetic repair can lead to a double-strand break in any one of the chromosomes. Because it corrects errors in genetic material as well as ensures the functioning of cells, homologous recombination is important for cell function. The second process that results in eukaryotic cells producing DSB is non-homologous ending joining. This is a type of DNA repair in which two pieces of DNA that have been broken are joined together using a method that doesn’t involve homologous DNA chromosomes. (Hendricks and al., 2002). It is crucial to restore the integrity of DNA and provide protection against damage. Cont…..

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