A cell acquires a mutation that inactivates its only AP endonuclease enzyme. Which of the following is the cell most likely to be more sensitive to? The Impact of Inactivation of AP Endonuclease Enzyme on Cell Sensitivity

Study of the Effects of Inactivating AP Endonuclease Enzyme Enzyme on Cell Sensitivity

The relationship between AP enzyme inactivation (APE), cell sensitivity, and AP endonuclease has been more extensively studied over the past few years. APE, an enzyme that is involved in DNA repair, is crucial for genomic stability. APE deactivation makes cells more susceptible to various DNA damaging agents as well other stresses. Chen and colleagues (2019) found that APE inactivation can make cells more sensitive to UV radiation. APE activation increased DNA damage susceptibility and sensitization in cells, according to a study by Chen et al. (2019). He et. al. APE activation may make cells more vulnerable to hydrogen peroxide. This is an environmental oxidant. APE inactivation can make cells sensitive to different types of stress, as well DNA-damaging agents. Zhang et. al. APE inactivation was shown to increase cells’ sensitivity to osmotic pressure (2020). Wang et. al. APE Inactivation demonstrated the cell’s sensitivity to oxidative stress in a study by Wang et al. (2021). Cont….