Basic Drugs are Protonated at pH 7.06

You can find drugs in either a protonated or deprotonated state depending on your environment. A key factor for determining what percentage of drug will be protonated at any given pH is the pK. The percentage of basic drugs with a pK 8.66 can be used to calculate the protonation rate at pH 7.06. The Henderson-Hasselbalch equation can be used to solve for the percentage of a drug that is protonated at a given pH (Fine, 2017). The equation can be expressed as pH = pK+ log[Drug Protonated]/[Drug Deprotonated]). This equation is rearranged so that you can calculate the percent of drug protonated at pH 7.06. [Drug Protonated]/[Drug Deprotonated] ratio. The ratio can be then converted into a percentage. Using the Henderson-Hasselbalch equation, the