A 62-year-old man with bilateral pneumonia cough does not respond to over-the-counter medication. He is given a standard dosage of oral codeine to relieve the cough. A few days into treatment, the patient becomes unresponsive and develops a life-threatening morphine intoxication. Discuss why this patient has morphine intoxication, how you treat the intoxication, and how you test for CYP2D6 activity. Would you try any other members of the family? Why or why not? Would you push for different drug sensitivities? If so, what would you consider testing for? Morphine Intoxication in a 62-Year-Old Man with Bilateral Pneumonia: Causes, Treatments, and Drug Sensitivity Testing

Morphine Intoxication in a 62-Yr-Previous Man with Bilateral Pneumonia: Causes, Remedies, and Drug Sensitivity Testing 

A 62-year-old man with bilateral pneumonia who didn’t reply to over-the-counter remedy was prescribed a normal dosage of oral codeine to alleviate his cough. Sadly, a couple of days into the therapy, the affected person turned unresponsive and developed a life-threatening morphine intoxication. This unlucky response may be attributed to the affected person’s distinctive genetic predisposition and ignorance of the potential for such an adversarial response. Morphine intoxication happens when a person is extra delicate to the drug as a result of presence of an enzyme deficiency of their physique, similar to CYP2D6. This enzyme is answerable for the metabolism of codeine and different opioids and is thought to be extremely variable between people, making some people extra delicate to those medicine than others (Lin, 2020; Singh et al., 2021). As such, when this affected person was prescribed a normal dosage of codeine, he was seemingly extra delicate to the drug as a result of his CYP2D6 deficiency, resulting in the life-threatening morphine intoxication. To deal with the morphine intoxication, you will need to first affirm the presence of CYP2D6 deficiency via a genetic take a look at. This may permit for a tailor-made therapy plan that may cut back the danger of additional adversarial reactions. Moreover, you will need to monitor the affected person’s very important indicators and supply supportive care, similar to oxygen, fluids, and air flow, as wanted (Lin, 2020). Cont…